What's the rare genetic disorder that claimed Luxembourg prince's life
What's the story
Prince Frederik of Luxembourg, the youngest son of Prince Robert and Princess Julie of Nassau, passed away on March 1 in Paris.
He died after a prolonged battle with POLG mitochondrial disease, a rare genetic disorder.
His family announced the news in an emotional statement on the POLG Foundation's website.
Diagnosed at 14, Frederik dedicated his life to campaigning for research and awareness about POLG mitochondrial disease.
He founded the POLG Foundation in 2022 to fight the incurable disease.
Advocacy
A life dedicated to advocacy and awareness
"Even in his last moments, his humor and boundless compassion compelled him to leave us with one last laugh...to cheer us all up," Prince Robert said.
He also revealed that Frederik, realizing his time was short, called his family members to his room "to speak to him one last time" on February 28, the day before his death.
His last messages were "kind, wise, and instructive," Robert continued.
Frederik was born with POLG Mitochondrial Disease, which wasn't initially diagnosed.
Disease details
POLG mitochondrial disease: A closer look
It was only when he turned 14 that the disease became more apparent and was formally diagnosed.
POLG mitochondrial disease is a genetic disorder that stops the body from generating enough energy, causing organs to fail.
It is a result of mutations in the POLG gene that affect mitochondria—the body's power source.
Symptoms differ, but common ones include muscle weakness, seizures, and liver failure.
There's no known cure; the condition deteriorates with time and affects about 1 in 5,000 people.
Ongoing efforts
Frederik's legacy continues through the POLG Foundation
After Frederik's death, the POLG Foundation said it would continue its work in his name. The foundation funds research for mitochondrial diseases and helps other families who endure similar genetic suffering.
"We will be resolutely focused on alleviating suffering for the POLG community and other conditions associated with mitochondrial diseases," Prince Robert vowed, ensuring his son's legacy lives on through continued advocacy and support.