This vaccine promises to prevent stroke, heart attacks
What's the story
In a major breakthrough in the battle against cardiovascular diseases, researchers in China have developed a vaccine to fight the buildup of fatty plaque in arteries.
The condition, called atherosclerosis, causes blood clots, strokes, and heart attacks - all of which are among the leading causes of death globally. The research was published in the journal Nature.
Trial results
Vaccine shows promise in preclinical trials
The vaccine, developed by scientists at Nanjing University of Science and Technology, has shown promise in reducing the development of atherosclerosis in mice.
The researchers said, "Our nano-vaccine design and preclinical data present a potential candidate for prophylactic treatment for atherosclerosis."
They found that the vaccine significantly slowed plaque progression and atherosclerosis development in mice on a high cholesterol diet.
Mechanism
How does the vaccine work?
The vaccine works by helping the body absorb an antigen and adjuvant, which then stimulates immune system's dendritic cells.
This activates T cells, resulting in the production of antibodies against P210.
The researchers explained, "In studying the vaccinations against atherosclerosis, an ongoing challenge is deciphering the mechanism of action - a prerequisite for translation of a vaccination protocol to humans."
Health crisis
Heart attacks on the rise among young adults
In India, heart attacks among young adults and those in their 30s and 40s have witnessed a sharp rise.
An October 2023 medical study found that heart attacks accounted for up to 45% of deaths in the 40-69 years age group.
Contributing factors include an unhealthy cholesterol and trans-fat rich diet, sedentary lifestyle, excessive alcohol consumption, and smoking.
Additional risks
Other factors contributing to heart attacks
Genetic predisposition and family history of heart attacks, high blood pressure, and environmental factors like air pollution can also lead to heart attacks.
Modern diets often include fast foods and sugary drinks that cause obesity, high blood pressure, and unhealthy lipid profiles among young adults.
Further, chronic stress caused by substance abuse can adversely affect heart health in more ways than one.