NewsBytes
    Hindi Tamil Telugu
    More
    In the news
    Narendra Modi
    Amit Shah
    Box Office Collection
    Bharatiya Janata Party (BJP)
    OTT releases
    Hindi Tamil Telugu
    NewsBytes
    User Placeholder

    Hi,

    Logout

    India
    Business
    World
    Politics
    Sports
    Technology
    Entertainment
    Auto
    Lifestyle
    Inspirational
    Career
    Bengaluru
    Delhi
    Mumbai

    Download Android App

    Follow us on
    • Facebook
    • Twitter
    • Linkedin
    Home / News / India News / Zydus Cadila's COVID-19 vaccine found safe, going into Phase-2 trial
    Next Article
    Zydus Cadila's COVID-19 vaccine found safe, going into Phase-2 trial

    Zydus Cadila's COVID-19 vaccine found safe, going into Phase-2 trial

    By Shubham Sharma
    Aug 05, 2020
    08:41 pm

    What's the story

    Indian drug company Zydus Cadila has completed early-stage human trials with its indigenously developed COVID-19 vaccine.

    The shot, according to a regulatory filing by the firm, was found to be safe in the study and will now be going into the second phase of clinical trials which will begin tomorrow, August 6, 2020.

    Here is all you need to know about it.

    Details

    Vaccine doses well tolerated by volunteers in Phase 1

    In the regulatory filing, Cadila Healthcare said that the doses of the vaccine administered to healthy volunteers in the Phase-1 clinical trial, which began on July 15, 2020, have been well tolerated.

    The safety level of the doses of the shot, officially dubbed ZyCoV-D, was endorsed by an external and independent data safety monitoring board, Reuters said in a report.

    Milestone

    This is a major milestone: Zydus Cadila Chairman

    Speaking on the development, Pankaj Patel, the Chairman of Zydus Cadila, said that this is an important milestone.

    "All the subjects in Phase-1 clinical trial were closely monitored in a clinical pharmacological unit for 24 hours post-dosing for safety and for 7 days thereafter, and the vaccine was found to be very safe," Patel said in a statement.

    Second phase

    Second phase will establish efficacy of the vaccine

    Now, with Phase-1 out of the way, Zydus Cadila will proceed with the second, mid-stage trial.

    The study will commence on August 6, 2020, and will focus on "evaluating the safety and immunogenicity of the vaccine in a larger population," Patel noted.

    This trial will have more than 1,000 participants and help researchers determine whether the shot generates an immune response or not.

    Animal trials

    In animal trials, ZyCoV-D was found effective

    Notably, in pre-clinical animal trials involving mice, rabbits, guinea pigs, ZyCoV-D was found to be safe and effective.

    The shot was able to generate a high level of neutralizing antibodies in the subjects, which is what we humans also need to fight off the novel coronavirus.

    The results on the vaccine's effectiveness might come post Phase-2 trials, sometime in October-November.

    Phase 3

    Then, Phase-3 will begin and continue until March 2021

    After Phase-2, the vaccine, if proved effective and cleared by Drug Controller General of India, will go into Phase-3 trials involving thousands of volunteers.

    This phase is expected to be completed by February/March 2021, following which the vaccine might become available.

    "We are looking at about seven or a little more than seven months for the vaccine, provided the data is encouraging," Patel had said last month.

    Other vaccines

    Bharat Biotech's COVAXIN is also in Phase-2 now

    Along with Cadila's shot, the COVID-19 vaccine from Bharat Biotech and the National Institute of Virology has also moved into Phase-2 clinical trials.

    These are the only two Indian shots that are moving through human trials at this stage.

    Globally, there are 24 other candidates in human trials, including those from UK's Oxford University and America's Moderna Therapeutics.

    Facebook
    Whatsapp
    Twitter
    Linkedin
    Related News
    Latest
    Zydus Cadila
    COVID-19
    Moderna Therapeutics
    COVID-19 Vaccine

    Latest

    KL Rahul averages 74.23 versus MI in IPL: Key stats  KL Rahul
    Mysore Rajamata donates 100kg silver lamps to Tirumala temple  Tirumala Tirupati Devasthanams
    2 trains escape derailments in UP: How loco-pilots averted disasters   Indian Railways
    England's XI for Zimbabwe Test features uncapped Sam Cook: Details England Cricket Team

    Zydus Cadila

    GSK recalls popular antacid Zinetac amid concerns over cancer-causing substance India
    COVID KAVACH ELISA: First Indian antibody detection kit for coronavirus Harsh Vardhan
    India's second COVID-19 vaccine cleared for human trials: Details here COVAXIN
    COVID-19 vaccine: What are the latest updates? Bharat Biotech

    COVID-19

    This device can 'disinfect' your home products with UV light World Health Organization
    SA Women to start training ahead of proposed England tour Cricket: News, Stats and more!
    Mohammad Amir returns two negative COVID-19 tests Mohammad Amir
    AIIMS Nagpur develops smart band to monitor COVID-19 patients All India Institute Of Medical Sciences (AIIMS)

    Moderna Therapeutics

    US begins human trials of coronavirus vaccine: Details here Health & Wellness
    COVID-19 vaccine not guaranteed, says leading world health expert World Health Organization
    Moderna's COVID-19 vaccine gets FDA nod for phase 2 trial Oxford University
    Moderna's COVID-19 vaccine shows 'positive' results in human trials United States of America

    COVID-19 Vaccine

    Remdesivir reportedly approved for COVID-19 treatment in India United States of America
    Moderna's COVID-19 vaccine to go into final-stage trials in July Vaccine
    Oxford's COVID-19 vaccine: All you need to know Oxford University
    Indian Premier League (IPL) Celebrity Hollywood Bollywood UEFA Champions League Tennis Football Smartphones Cryptocurrency Upcoming Movies Premier League Cricket News Latest automobiles Latest Cars Upcoming Cars Latest Bikes Upcoming Tablets
    About Us Privacy Policy Terms & Conditions Contact Us Ethical Conduct Grievance Redressal News News Archive Topics Archive Download DevBytes Find Cricket Statistics
    Follow us on
    Facebook Twitter Linkedin
    All rights reserved © NewsBytes 2025