What is Angelman syndrome? Rare condition affecting Colin Farrell's son
What's the story
Actor Colin Farrell's son, James, has been diagnosed with Angelman syndrome, a rare genetic disorder that affects brain development. The condition, which causes severe physical and learning disabilities, is caused by changes in the UBE3A gene. Farrell recently launched the Colin Farrell Foundation to support individuals with intellectual disabilities like his son. Know more about the disease here.
Foundation
Farrell's foundation aims to support those with intellectual disabilities
The Colin Farrell Foundation aims to increase Medicaid funding, enhance housing options, and raise wages for caretakers. The actor hopes that through these efforts, the foundation can provide necessary support for individuals with intellectual disabilities. He was inspired to establish this initiative due to his personal experience with his son James.
Early signs
Farrell noticed early signs of Angelman syndrome in his son
Farrell recalled noticing early signs of Angelman syndrome in his son: "James was a very silent baby... he didn't make any sounds at all. I thought I'd hit the lottery... I thought I have a chill child who's not going to keep me up at night." However, when James failed to meet developmental milestones, Farrell and his family realized something was amiss.
Disorder details
Angelman syndrome: Symptoms and causes
Angelman syndrome was first identified in 1965 by British doctor Harry Angelman. It presents various symptoms including developmental delays, severe speech impairment, balance problems, seizures, and issues with the gastrointestinal system, bones, and eyes. Some individuals may exhibit unique behaviors such as hand flapping or holding their arms up while walking.
Genetic changes
Angelman syndrome is a genetic disorder
A child usually inherits two copies of the UBE3A gene, one from each parent. Angelman syndrome occurs when the maternal copy of the UBE3A gene is missing or damaged. In rare instances, it can also result from having two paternal copies of the gene. The exact cause of these genetic changes often remains unknown, though a family history of the condition may increase the risk. It can't be cured.